Award
NIH Reporter #4R01AI165692-04
Automated chemo-enzymatic synthesis of N-glycans for host-pathogen interactions
Recipient
University of Georgia
Award Amount
$849,692.00
Ceiling
$849,692.00
Awarded
August 12, 2025
Identifier
4R01AI165692-04
The award funds the University of Georgia to develop automated chemoenzymatic synthesis methods for N-glycans to study host-pathogen interactions, especially influenza A virus binding, to support pandemic preparedness and vaccine development.
Description
This project develops chemoenzymatic methodologies to prepare a wide range of N-glycans found in the respiratory tract of humans and relevant animals, using a new synthetic paradigm called 'Stop-and-Go-Chemoenzymatic Glycosylation'. An automation platform will be developed to increase synthesis speed, enabling the preparation of complex N-glycans for host-pathogen studies, particularly focusing on influenza A virus receptor usage and aiding in surveillance, prevention, and intervention strategies.