Award
National Institute of Allergy and Infectious Diseases 1R21AI187932-01
Contribution of RpoS to persistence of Borrelia burgdorferi in mammals
Recipient
University of Connecticut School of Medicine, Farmington, CT
Award Amount
$457,875.00
Ceiling
$457,875.00
Awarded
June 27, 2025
Identifier
1R21AI187932-01
This award funds research on the role of the RpoS gene in the persistence of Borrelia burgdorferi, the Lyme disease agent, in mammals to understand chronic infection mechanisms.
Description
Borrelia burgdorferi (Bb), the causative agent of Lyme disease, is maintained in nature by an enzootic cycle involving a tick vector and a mammalian host. The proposed experiments aim to shed light on how LD spirochetes persist in nature and human tissues, contributing to chronic clinical manifestations.