Award
National Eye Institute 1K99EY037781-01A1
Hormonal Dynamics and Extracellular Vesicle Function in Keratoconus: Exploring Pathophysiology and Developing Targeted Therapies
Recipient
Schepens Eye Research Institute
Award Amount
$132,837.00
Ceiling
$132,837.00
Awarded
June 12, 2026
Identifier
1K99EY037781-01A1
Research project funded by the National Eye Institute to study hormonal and extracellular vesicle roles in keratoconus, aiming to understand disease mechanisms and develop targeted therapies.
Description
This project explores the role of sex hormones and genetic mutations in keratoconus (KC), focusing on miRNA sorting within extracellular vesicles (EVs) and their functional roles using a 3D collagen hydrogel model. It aims to identify cell-specific responses to hormones and EVs, providing insights into disease pathology and potential therapeutic targets.