Award
National Institute of Arthritis and Musculoskeletal and Skin Diseases 5R01AR079839-05
Identification of Novel Genes Impacting Osteoblast Activity
Recipient
University of Colorado Denver
Award Amount
$573,163.00
Ceiling
$573,163.00
Awarded
July 10, 2025
Identifier
5R01AR079839-05
NIH grant awarded to University of Colorado Denver for research on genetic regulators of osteoblast function to develop safer, more effective osteoporosis treatments.
Description
This NIH project focuses on genetic and molecular analysis to identify therapeutic targets for osteoporosis, utilizing advanced sequencing and bioinformatics techniques. The project aims to identify key genes and pathways controlling osteoblast differentiation, migration, and mineralization through high-resolution QTL mapping and Bayesian network analyses based on single-cell RNA and ATAC sequencing. The goal is to discover therapeutic targets to enhance bone formation in osteoporosis.