Award
NIH Reporter #5R01AI147118-09
Mechanobiology of the immune synapse: signal integration via actin dynamics
Recipient
Children's Hospital of Philadelphia, Philadelphia, PA, United States
Award Amount
$413,263.00
Ceiling
$413,263.00
Awarded
November 01, 2024
Identifier
5R01AI147118-09
NIH awarded a research grant to study how mechanical forces affect T cell activation via actin dynamics and TCR signaling, aiming to elucidate the biochemical and mechanical pathways involved.
Description
This NIH research grant focuses on the mechanobiology of the immune synapse, specifically how mechanical force influences T cell activation through actin dynamics and TCR signaling. The project aims to understand biochemical and mechanical circuits in TCR signal transduction that translate physical characteristics of TCR-pMHC interactions into cellular responses.