Award
National Institute of Allergy and Infectious Diseases 3U01AI155299-05S1
Glucagon-Like Peptide-1 Receptor Agonist Treatment in Adult, Obesity-Related, Symptomatic Asthma
Recipient
Vanderbilt University Medical Center
Award Amount
$686,053.00
Ceiling
$686,053.00
Awarded
August 12, 2025
Identifier
3U01AI155299-05S1
A research project funded by NIAID to study the efficacy of GLP-1 receptor agonists in improving asthma control and reducing airway inflammation in obese adults with asthma, potentially leading to new therapeutic approaches.
Description
This project aims to evaluate the impact of GLP-1 receptor agonists (GLP-1RA) on asthma control and airway inflammation in obese adults through a 12-week randomized, double-blind, placebo-controlled trial of oral semaglutide 7 mg daily. Outcomes include asthma control (ACQ-7) and serum periostin levels, with tissue analysis via RNA sequencing to assess inflammation in airway and adipose tissues.