Award
National Institute on Aging 5F31AG087533-02
Epigenetic and cellular mechanisms of age-related memory updating impairments
Recipient
PENNSYLVANIA STATE UNIVERSITY, THE
Award Amount
$37,770.00
Ceiling
$37,770.00
Awarded
August 01, 2025
Identifier
5F31AG087533-02
Research project funded by the National Institute on Aging to study epigenetic and cellular mechanisms underlying age-related memory impairments, aiming to develop therapeutics for memory disorders such as Alzheimer's disease.
Description
This project investigates epigenetic mechanisms, focusing on HDAC3 activity, in age-related memory updating deficits using a novel paradigm called the Objects in Updated Locations (OUL) task in mice. The study aims to understand neuronal ensemble dynamics and gene regulation during memory updating in aged hippocampus, which could lead to therapeutic strategies for memory disorders.