Award
NIH Reporter #4R01NS132784-02
Biophysical Mechanisms of Cortical MicroStimulation
Recipient
Massachusetts General Hospital
Award Amount
$1,033,160.00
Ceiling
$1,033,160.00
Awarded
August 31, 2026
Identifier
4R01NS132784-02
The award funds research to elucidate the mechanisms of cortical microstimulation using electrophysiology and computational modeling to improve therapeutic brain stimulation techniques.
Description
This project aims to understand the biophysics of cortical stimulation through single-cell electrophysiology in human and mouse cortex, pharmacology, optical physiology, and computational modeling to identify mechanisms underlying electrical stimulation. The research tests hypotheses about excitatory and inhibitory neuron dynamics induced by direct local electrical stimulation (DLES) and develops neural network models to predict cortical responses and design stimulation patterns for therapeutic applications.