Award
NIH Reporter #5R01MH131623-03
Uncovering the origin of hypermutability in adult brains
Recipient
Mayo Clinic Rochester
Award Amount
$844,959.00
Ceiling
$844,959.00
Awarded
December 10, 2025
Identifier
5R01MH131623-03
Research project investigating the origins and implications of hypermutability in adult brains, focusing on genomic mosaicism and its relation to aging and neurodegenerative diseases.
Description
The study aims to expand the set of hypermutable brains, analyze regional mutation distribution, identify cell types carrying mutations, and determine if mutations arise from clonally expanded cell lineages to understand brain development and aging.