Award
National Institute of Diabetes and Digestive and Kidney Diseases 5R01DK133480-04
Contribution of the sacral neural crest to the peripheral nervous system of the post-umbilical gastrointestinal tract
Recipient
California Institute of Technology, Pasadena, CA, United States
Award Amount
$556,439.00
Ceiling
$556,439.00
Awarded
March 23, 2026
Identifier
5R01DK133480-04
Research project funded by NIDDK to study sacral neural crest cell development in the gastrointestinal tract using advanced genetic and cellular techniques to understand enteric nervous system development and related disorders.
Description
This project aims to characterize the development of sacral neural crest cells into enteric neurons in the hindgut, compare their transcriptional profiles with vagal neural crest cells, and test the function of key transcription factors involved in their fate decisions. The study will utilize lineage labeling with RIA retroviruses, single-cell RNA sequencing, and CRISPR-Cas9 gene editing in chick models.