Award
National Institute of Allergy and Infectious Diseases 5R01AI099108-14
Transcriptional Regulation of Antibody Responses and Immunity
Recipient
University of Arizona, Tucson, AZ
Award Amount
$513,883.00
Ceiling
$513,883.00
Awarded
May 07, 2026
Identifier
5R01AI099108-14
This award funds research to understand the molecular and cellular mechanisms that regulate the duration of antibody-mediated immunity following vaccination, using advanced genetic and epigenetic techniques.
Description
The project aims to identify genetic factors and cellular events that control the duration of immunity after vaccination. It focuses on molecular programs and cellular trajectories leading to long-lived plasma cells, as well as transcriptional and epigenetic features of memory B cells that precede durable recall responses. The study employs single-cell transcriptional and epigenetic programs, classic model antigens, adjuvants, and genetic tools to manipulate genes in vivo. The goal is to develop rules to predict and optimize the duration of humoral immunity.