Award
National Institute of Allergy and Infectious Diseases (NIAID) 5K24AI141744-08
Understanding protection against norovirus at the maternal-child interface
Recipient
University of North Carolina at Chapel Hill
Award Amount
$197,612.00
Ceiling
$197,612.00
Awarded
March 27, 2026
Identifier
5K24AI141744-08
Research project investigating maternal protection against norovirus in early childhood by studying maternal antibodies, breastmilk components, and infant gut microbiome to identify interventions.
Description
This project builds upon patient-oriented research on viral gastroenteritis, focusing on maternal protection against norovirus (NoV) in early childhood. It aims to investigate maternal antibodies, bioactive components of breastmilk, and infant gut microbiome composition to identify future interventions. The research involves analyzing existing data and biobanked samples from a Nicaraguan birth cohort, elucidating differences in breastmilk oligosaccharides and NoV-specific antibodies, and understanding their contributions to NoV risk.