Award
National Institute of Allergy and Infectious Diseases 5R21AI188438-02
Insights into the origin of ACPAs in RA
Recipient
Johns Hopkins University, Baltimore, MD, United States
Award Amount
$232,875.00
Ceiling
$232,875.00
Awarded
January 02, 2026
Identifier
5R21AI188438-02
Research project funded by NIAID to study the origin of anti-citrullinated protein antibodies in rheumatoid arthritis, exploring their development from antibodies targeting carbamylated proteins.
Description
This project aims to elucidate the origin of ACPAs in rheumatoid arthritis (RA), potentially leading to new insights into autoimmune disease mechanisms and therapeutic targets. It investigates the hypothesis that ACPAs arise during affinity maturation of germline-encoded antibodies to carbamylated proteins, using RA-derived monoclonal ACPAs to support or discard this hypothesis.