Award
National Cancer Institute 7R01CA262873-05
Mdm2 Alternative Splicing in DNA Damage and Cancer
Recipient
Ohio State University
Award Amount
$464,185.00
Ceiling
$464,185.00
Awarded
September 11, 2025
Identifier
7R01CA262873-05
This NIH grant funds research on the role of MDM2 alternative splicing in DNA damage response and cancer, focusing on the p53 pathway and potential therapeutic targets.
Description
The proposed research will study the molecular connection between DNA damage, MDM2 isoform switching, p53, and cancer. The research aims to understand the regulation of the p53 pathway by MDM2-ALT1, the mechanism of its generation in cancer, and its potential as a therapeutic target using splice-switching oligonucleotides.