Award
NIH Reporter #1R01CA305930-01A1
Role of P4HA2 in metastatic dormancy
Recipient
ICHAN SCHOOL OF MEDICINE AT MOUNT SINAI
Award Amount
$827,111.00
Ceiling
$827,111.00
Awarded
July 21, 2026
Identifier
1R01CA305930-01A1
NIH grant awarded to ICHAN SCHOOL OF MEDICINE AT MOUNT SINAI to study the role of P4HA2 in metastatic dormancy, focusing on collagen modifications and tumor cell dormancy mechanisms to identify anti-metastatic targets.
Description
This project investigates the mechanisms of collagen modifications in the context of tumor dormancy. Outcomes will reveal how disseminated tumor cells regulate proline hydroxylation of collagen and the crosstalk with autophagy and mitochondria function. Findings will be applied towards finding novel anti-metastatic targets.