Award
National Institute on Aging 5U01AG086145-03
Impact of Circadian-Microbiome Interaction on the Gut-Pancreas Axis in Aging
Recipient
University of Texas Health Science Center Houston
Award Amount
$639,628.00
Ceiling
$639,628.00
Awarded
April 29, 2026
Identifier
5U01AG086145-03
Research funded by the National Institute on Aging to investigate the impact of circadian rhythm disruption and microbiome interactions on aging, focusing on the gut-pancreas axis, using mouse models and human studies to find anti-aging therapeutic targets.
Description
This project studies how food timing affects intestinal inflammation and pancreas aging in mice, establishing the role of microbial signaling in mediating the effects of host circadian disruption on the gut-pancreas axis in aging. It aims to identify mechanisms of healthy aging and targetable mechanisms for anti-aging therapies.