Award
Eunice Kennedy Shriver National Institute of Child Health and Human Development 5R21HD116113-02
Neural Mechanism of Impaired Satiation After Magel2 Mutation
Recipient
Haijiang Cai
Award Amount
$184,527.00
Ceiling
$184,527.00
Awarded
July 24, 2025
Identifier
5R21HD116113-02
Research project awarded to study neural mechanisms of impaired satiation due to Magel2 mutation, relevant to Prader-Willi and Shafer-Young Syndromes, using advanced imaging and electrophysiology techniques.
Description
This project aims to investigate the neural mechanisms underlying impaired satiation in models with Magel2 mutation, with potential implications for understanding Prader-Willi Syndrome and Shafer-Young Syndrome. The study involves in vivo calcium imaging and electrophysiology to analyze the activity of CeA PKC-δ neurons.