Award
NIH Reporter #5U01CA249955-05
Epigenetic contribution to the excess risk of MGUS in African Americans
Recipient
University of Alabama at Birmingham, Department of Pathology
Award Amount
$616,272.00
Ceiling
$616,272.00
Awarded
August 20, 2025
Identifier
5U01CA249955-05
This NIH grant funds research to understand epigenetic factors contributing to higher MGUS risk in African Americans, aiming to improve risk prediction and clinical management through biomarker development.
Description
The study aims to identify and characterize epigenetic marks contributing to the increased risk of monoclonal gammopathy of undetermined significance (MGUS) and multiple myeloma in high-risk populations, particularly African Americans. It leverages existing clinical data and biospecimens to explore DNA methylation signatures and develop biomarkers for better risk prediction and clinical management.