Award
National Institute of Allergy and Infectious Diseases 3U19AI162598-05S1
Bacterial and Host Heterogeneity in TB latency, persistence and progression
Recipient
Rutgers Biomedical and Health Sciences, Newark, NJ, United States
Award Amount
$38,013.00
Ceiling
$38,013.00
Awarded
August 20, 2025
Identifier
3U19AI162598-05S1
Research project investigating mechanisms of TB latency, persistence, and progression by studying bacterial and host heterogeneity to improve treatment outcomes.
Description
This project aims to identify common mechanisms by which Mycobacterium tuberculosis bacteria evade drug killing, potentially leading to relapse after treatment. It explores heterogeneity in TB disease states, host responses, bacterial genotypes, and phenotypes, focusing on transcriptional and metabolic programs that influence disease progression, immune evasion, drug tolerance, and treatment outcomes.