Award
National Institute on Drug Abuse 1R03DA064666-01
Longitudinal Multiparametric Magnetic Resonance Imaging of Outbred Rats with Variable Vulnerability to the Development of Oxycodone Addiction-like Behaviors
Recipient
University of California, San Diego
Award Amount
$239,125.00
Ceiling
$239,125.00
Awarded
February 20, 2026
Identifier
1R03DA064666-01
The project investigates brain differences related to vulnerability to oxycodone use disorder using MRI in genetically diverse rats, aiming to identify brain features linked to addiction vulnerability and resilience to inform personalized prevention and treatment.
Description
This research aims to investigate brain differences related to individual vulnerability to oxycodone use disorder using longitudinal multiparametric MRI in genetically heterogeneous rats from the NIDA-funded Rat Oxycodone Biobank. The study will assess baseline brain features and changes following extended oxycodone self-administration, focusing on vulnerability and resilience to addiction-like behaviors. The project will introduce MRI imaging into the research environment, complementing existing genomic and behavioral data, to enhance understanding of individual differences in opioid impact on the brain and inform personalized prevention and treatment strategies.