Award
NIH Reporter #5R35GM156320-02
Evolutionary Tradeoffs in Antibiotic Resistance
Recipient
Harvard Medical School, Boston, MA, United States
Award Amount
$483,340.00
Ceiling
$483,340.00
Awarded
January 12, 2026
Identifier
5R35GM156320-02
A research project funded by the National Institute of General Medical Sciences to study the evolutionary dynamics of antibiotic resistance in bacteria, aiming to inform new therapies and public health strategies.
Description
This project aims to deepen understanding of the evolutionary tradeoffs involved in antibiotic resistance, with implications for public health and clinical strategies. It explores tradeoffs in bacterial evolution focusing on antibiotic resistance, plasmids, horizontal gene transfer, and interactions with bacteriophages, including discovering new mobile genetic elements and their cargo, relating findings to the historical evolution of antibiotic resistance, laboratory evolution, and computational modeling.