Award
National Institute on Aging 5R01AG089192-02
Multidimensional predictive modeling to understand mechanisms of exercise response heterogeneity in older adults
Recipient
Florida Institute of Human and Machine Cognition
Award Amount
$1,470,001.00
Ceiling
$1,470,001.00
Awarded
August 08, 2025
Identifier
5R01AG089192-02
This NIH-funded project investigates the biological factors behind variability in exercise response among older adults using a two-phase clinical trial to improve health outcomes through targeted exercise interventions.
Description
Aging-related functional declines are thought to be caused by hallmark biological processes that manifest in physical, mental, and metabolic impairments, compromising healthspan and quality of life. Exercise is a promising multipotent treatment to mitigate aging hallmarks, but there is substantial variability in individual responsiveness. This project aims to use combined endurance and resistance training aligned with public health guidelines to better understand exercise response heterogeneity in older adults, with the goal of improving health benefits. The study will involve a 2-phase Sequential Multiple Assignment Randomized Trial (SMART) with clinical phenotyping and molecular analyses. Phase I will classify responders based on improvements in cardiorespiratory fitness (VO2max) and muscle quality. Phase II will test strategies to enhance responses among non-responders.