Award
National Institute of Allergy and Infectious Diseases 5R01AI176646-04
Understanding and optimizing antibody-based interventions against neonatal HSV infection
Recipient
Dartmouth College
Award Amount
$776,973.00
Ceiling
$776,973.00
Awarded
July 29, 2026
Identifier
5R01AI176646-04
This NIH-funded project at Dartmouth College seeks to optimize monoclonal antibody interventions to prevent neonatal HSV infection by studying antibody mechanisms and viral factors.
Description
The project aims to define and refine the means by which monoclonal antibodies (mAbs) can be used to prevent or reduce neonatal herpes simplex virus (nHSV) morbidity and mortality. It focuses on understanding the mechanisms of antibody action, including the role of viral Fc receptors and glycoprotein complexes, to optimize antibody-based interventions.