Award
NIH Reporter #1R01EB037601-01A1
The first safe and effective DNA-loaded lipid nanoparticles (DNA-LNPs)
Recipient
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
Awarded
May 27, 2026
Identifier
1R01EB037601-01A1
Development of DNA-loaded lipid nanoparticles for gene therapy to improve expression and reduce toxicity, targeting chronic diseases.
Description
This project involves developing DNA-loaded lipid nanoparticles (DNA-LNPs) for gene therapy, aiming to improve expression levels and reduce toxicity. The project is funded by NIH and targets chronic diseases such as atherosclerosis and emphysema. The goal is to create a new generation of DNA-LNPs that can match the performance of mRNA-LNPs and AAV vectors.