Award
National Institute of Neurological Disorders and Stroke 5R01NS131557-03
In Vivo Analyses of Kinase Signaling in Learning/Memory Circuitry
Recipient
Vanderbilt University, Nashville, TN, United States
Award Amount
$409,383.00
Ceiling
$409,383.00
Awarded
January 14, 2026
Identifier
5R01NS131557-03
The award funds research to genetically dissect kinase signaling pathways involved in learning and memory using advanced biosensors and imaging techniques in model organisms, focusing on PKA, ERK, and CaMKII kinase pathways in brain circuits.
Description
This project uses separation of phases-based activity reporter of kinase (SPARK) biosensors to visualize kinase activity in vivo, focusing on PKA, ERK, and CaMKII pathways. The research involves imaging kinase signaling in the Drosophila mushroom body, dissecting activity-dependent mechanisms, and testing interventions in learning/memory and seizure models.