Award
National Institute of Arthritis and Musculoskeletal and Skin Diseases 5U01AR080969-04
Bisphosphonate Use to Mitigate Bone Loss Secondary to Bariatric Surgery
Recipient
Wake Forest University
Award Amount
$591,370.00
Ceiling
$591,370.00
Awarded
May 04, 2026
Identifier
5U01AR080969-04
This NIH grant funds a study to test bisphosphonate therapy to reduce bone loss after bariatric surgery, involving 120 patients and aiming to impact clinical practice and biological understanding.
Description
The project involves testing the efficacy of bisphosphonate therapy (risedronate) in reducing bone loss after bariatric surgery. The study will involve 120 middle-aged and older patients, with outcomes assessed at baseline, 6, and 12 months. Primary outcome: change in total hip areal BMD measured by DXA. The project aims to influence clinical practice and understand mechanisms of bone-muscle crosstalk.