Award
National Institute of Allergy and Infectious Diseases 7R01AI151588-06
Donor-specific B cells in Transplantation.
Recipient
CASE WESTERN RESERVE UNIVERSITY, CLEVELAND, OH, UNITED STATES
Award Amount
$467,791.00
Ceiling
$467,791.00
Awarded
April 22, 2025
Identifier
7R01AI151588-06
This award supports research to understand donor-specific B cell responses in kidney transplant recipients to improve graft survival and develop personalized therapies to prevent rejection.
Description
The research aims to identify key characteristics of donor-specific B cell responses in kidney transplant recipients to understand their role in graft stability versus rejection. It involves analyzing Ig sequences and phenotypes of B cells, studying changes over time, and testing properties of monoclonal DSA to assess pathogenicity. The goal is to develop personalized therapeutic strategies to promote protective responses and mitigate rejection.