Award
NIH Reporter #1R15HL188532-01
Reduced Complex N-Glycosylation, -Adrenergic Receptor Sensitivity, and Heart Failure
Recipient
Wright State University, Dayton, OH, United States
Award Amount
$552,338.00
Ceiling
$552,338.00
Awarded
August 13, 2026
Identifier
1R15HL188532-01
The award supports research investigating how reduced complex N-glycosylation affects -adrenergic receptor sensitivity and contributes to heart failure, aiming to identify early biomarkers and mechanisms of disease progression.
Description
This project proposes that loss of complex N-glycosylation enhances -adrenergic receptor signaling and triggers disease onset, contributing to heart failure progression. The research will test hypotheses related to glycosylation's effect on receptor signaling and cardiac function using molecular, cellular, and organ-level studies.