National Institute of General Medical Sciences 5R35GM145379-05

Microvascular Leakage in Hemorrhagic Shock and Trauma

NIH awarded a $375,000 grant to University of South Florida for research on microvascular leakage in trauma and hemorrhagic shock, aiming to identify molecular targets and develop personalized therapies to improve patient outcomes.

Description

This NIH R35 MIRA grant application addresses a fundamental gap in understanding trauma-induced microvascular leakage, a hallmark of the systemic inflammatory response. The long-term goal is to identify novel targets to ameliorate microvascular leakage following traumatic injury, thereby improving trauma patient outcomes. The research will expand knowledge of cellular and molecular signals controlling microvascular permeability, including the effects of alcohol intoxication. The study will utilize RNA-Seq, proteomics, metabolomics, and lipidomics to analyze experimental models of trauma and tissues from trauma patients, aiming to identify molecules associated with hyperpermeability and develop personalized therapeutic strategies.

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