Award
National Heart, Lung, and Blood Institute 11467140
Intramuscular vs. Enteral Penicillin Prophylaxis to Prevent Progression of Latent Rheumatic Heart Disease: A non-inferiority randomized trial. (GOALIE)
Recipient
Cincinnati Children's Hospital Medical Center
Award Amount
$135,660.00
Ceiling
$135,660.00
Awarded
February 24, 2026
Identifier
11467140
NIH grant awarded to Cincinnati Children's Hospital Medical Center for a clinical trial comparing intramuscular and oral penicillin to prevent progression of latent Rheumatic Heart Disease in children, funded by NHLBI.
Description
This is a NIH grant project focusing on a clinical trial comparing intramuscular and oral penicillin for latent Rheumatic Heart Disease. The project aims to determine if oral penicillin is non-inferior to intramuscular penicillin in preventing disease progression. The study will conduct school-based echocardiographic screening of approximately 100,000 children. The project builds on previous successful screening and adherence strategies. The project will also examine economic and patient-reported outcomes. The funding agency is the National Heart Lung and Blood Institute (NHLBI).