Award
National Institute of Diabetes and Digestive and Kidney Diseases 5R01DK132120-04
Developmental regulation of epithelial polarization by pre-mRNA splicing
Recipient
Duke University, Durham, NC, United States
Award Amount
$466,159.00
Ceiling
$466,159.00
Awarded
January 27, 2026
Identifier
5R01DK132120-04
Research project focused on understanding the genetic and cellular mechanisms behind epithelial cell polarization in the intestine, with implications for diseases like cancer and malabsorption syndromes.
Description
The project aims to uncover genetic and cellular mechanisms controlling the maturation of apical membrane polarization and apical endocytosis during development of the vertebrate intestine. It seeks to understand the origin of diseases related to impaired absorption and cell polarity defects such as cancer, nutrient malabsorption, and congenital diarrheal disorders.