Award
National Institute of Neurological Disorders and Stroke 5R01NS129722-04
Serotonergic circuit mechanisms in postictal recovery and arousal
Recipient
University of Iowa
Award Amount
$526,125.00
Ceiling
$526,125.00
Awarded
December 18, 2025
Identifier
5R01NS129722-04
Research project funded by NINDS to study CO2-arousal impairment and neuronal circuit mechanisms in epilepsy models to prevent seizure-induced death.
Description
This project aims to understand the mechanisms of impairment of CO2-arousal in relevant animal models, which may inform risk stratification and prophylactic strategies against SUDEP. The research focuses on mouse models of temporal lobe epilepsy (TLE) and Dravet Syndrome (DS), assessing how seizures impair CO2-arousal, neuronal function in arousal system components, and whether stimulating specific circuits can prevent seizure-induced death.