Award
National Cancer Institute 1R37CA299197-01A1
Role of ATAD2 in Prostate Cancer Progression and Metastasis
Recipient
ICHAN SCHOOL OF MEDICINE AT MOUNT SINAI
Award Amount
$682,886.00
Ceiling
$682,886.00
Awarded
April 21, 2026
Identifier
1R37CA299197-01A1
This award funds research on the role of ATAD2 in prostate cancer progression and metastasis, focusing on bone colonization and immune evasion to develop targeted therapies.
Description
The project aims to understand the functional determinants of progression to lethal metastatic prostate cancer to develop more effective therapies. Preliminary studies indicate that ATAD2, an epigenetic and transcriptional regulator, is a critical mediator of metastasis and immune responses. The research will focus on its role in bone colonization and immune evasion, using advanced models such as syngeneic mouse models, ex-vivo epigenetic editing, human organoids, and tissue engineering.