National Institute of Environmental Health Sciences 1R41ES038047-01

Rapid and economical system for preparation of PFAS samples to lower the Method Detection Limit

Development of a cost-effective PFAS sample preparation system that lowers detection limits and increases throughput using innovative technology, enhancing environmental and public health monitoring.

Description

This project aims to develop an innovative and cost-effective PFAS sample preparation (C-PREP) system that significantly lowers the Method Detection Limit (MDL) and enhances high-throughput capabilities. Utilizing InnovaPrep’s Concentrating Pipette instrument with a novel “loosely loaded Concentrating Pipette Tip (CPT)” design called HIFI-SPE, the system will overcome limitations of traditional solid-phase extraction (SPE) methods by reducing sample loading times while maintaining binding efficiency and sensitivity. Key innovations include sorbent-loaded hollow fiber filters for solid-phase extraction (HIFI-SPE), integration with patented Wet Foam Elution technology, and the ability to simultaneously capture and elute PFAS from both free water and environmental particles. The approach includes optimizing sorbent materials, developing solvent-resistant components, and utilizing computational fluid dynamics to refine design parameters. Preliminary data demonstrates the feasibility of processing 500 mL samples in minutes with high concentration factors, representing a significant advance in PFAS detection. This collaborative effort between InnovaPrep LLC and the University of Kansas will result in a scalable, automated system that provides faster, more sensitive PFAS analysis, addressing critical needs in environmental and public health monitoring.

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