Award
NIH Reporter #5R01AI171408-05
The role of mammarenavirus defective interfering particles in protecting host fitness and the host-driven post-translational modifications that regulate their formation and function
Recipient
University of Vermont & St. College
Award Amount
$598,271.00
Ceiling
$598,271.00
Awarded
August 14, 2026
Identifier
5R01AI171408-05
This NIH grant supports research on mammarenavirus defective interfering particles, focusing on their regulation by host cellular machinery and their role in host fitness and viral pathogenesis.
Description
The project aims to identify the cellular machinery responsible for regulating arenavirus defective interfering particles (DIPs) production and to understand their impact on reservoir host fitness. The research will explore how host tyrosine kinases and NEDD4 family E3 ubiquitin ligases regulate DIP formation, expand the map of arenavirus post-translational modifications, and connect these findings to pathogenesis in rodents and humans.