Award
National Eye Institute 5R01EY037682-02
Gene therapy targeting CFH and lipoprotein dynamics in AMD
Recipient
Duke University
Award Amount
$682,606.00
Ceiling
$682,606.00
Awarded
July 22, 2026
Identifier
5R01EY037682-02
This NIH-funded project at Duke University focuses on gene therapy for age-related macular degeneration (AMD) by targeting CFH and lipoprotein pathways to provide preclinical evidence and mechanistic insights for new treatments.
Description
The proposed studies aim to establish preclinical efficacy of a lipid metabolism modulator and a complement regulator to treat AMD, and to mechanistically determine the interaction of pathways regulating the complement system and lipid metabolism in AMD development and progression. This research aligns with NEI's high priority area, From Genes to Disease Mechanism.