Award
National Institute on Aging 5R01AG074330-05
Upregulated Norepinephrine Synthesis Capacity in Aging
Recipient
Brandeis University
Award Amount
$1,382,890.00
Ceiling
$1,382,890.00
Awarded
April 08, 2026
Identifier
5R01AG074330-05
Research project funded by the National Institute on Aging to study norepinephrine synthesis and its impact on cognitive resilience and tau pathology in aging and Alzheimer's disease using advanced imaging techniques.
Description
This project investigates the relationship between norepinephrine synthesis capacity and locus coeruleus structure, and the role of elevated norepinephrine synthesis in cognitive resilience and resistance to tau pathology spread in aging and Alzheimer’s disease. The study employs multimodal imaging techniques including MRI, PET scans with [18F]Fluoro-m-tyrosine and [18F]MK-6240, and plasma Ab42/40 measures.