Award
National Institute of General Medical Sciences 2R35GM119707-11
Mapping the Structural Basis for Mechanistic Diversity in Metalloenzyme Superfamilies
Recipient
Pennsylvania State University, The
Award Amount
$566,332.00
Ceiling
$566,332.00
Awarded
June 12, 2026
Identifier
2R35GM119707-11
Research project funded by NIGMS to study metalloprotein evolution, enzyme mechanisms, and metal trafficking to enable novel antibiotic development, biocatalysis, and protein engineering.
Description
This project aims to understand how metalloproteins evolve and adapt to use different metals or none at all, elucidate new enzyme activities in structural scaffolds, and study metalloenzyme superfamilies relevant to biocatalysis and metal trafficking. The research will facilitate enzyme inhibition in bacterial pathogens, use of enzymes in chemical synthesis, and understanding of metal trafficking proteins, with applications in biocatalyst evolution, antibiotic design, and rare-earth extraction.