Award
National Institute of Allergy and Infectious Diseases 1R21AI190998-01A1
Defining the mechanism of CNS inflammation induced by colitis
Recipient
Loyola University Chicago, Maywood, IL, United States
Award Amount
$423,500.00
Ceiling
$423,500.00
Awarded
February 02, 2026
Identifier
1R21AI190998-01A1
Research project funded by NIAID to study the mechanisms linking bowel inflammation to brain inflammation in IBD, with goals to identify serum factors and study CNS cell impacts for therapeutic development.
Description
This project seeks to understand how inflammation of the bowels can induce inflammation in the brain, aiming to understand mechanisms that can be treated therapeutically to improve the lives of patients with inflammatory bowel diseases (IBD). The research focuses on CNS inflammation mechanisms in IBD models, identifying serum factors inducing CNS inflammasome activation, and using cell lineage-specific biosensors to study CNS cell populations.