Award
National Heart, Lung, and Blood Institute 5F32HL170648-03
The functional role of DDX41 in myelodysplastic syndromes
Recipient
Northwestern University, Chicago, IL, United States
Award Amount
$88,360.00
Ceiling
$88,360.00
Awarded
August 15, 2025
Identifier
5F32HL170648-03
Research project awarded to study the role of DDX41 in myelodysplastic syndromes and develop targeted therapies for related hematologic malignancies.
Description
The project focuses on studying the functional role of DDX41 in myelodysplastic syndromes, including mechanisms involving G4 accumulation and erythropoiesis. The research aims to develop targeted therapies for DDX41 mutation-related hematologic malignancies. The project involves generating lineage-specific DDX41 knockout mice and mechanistic studies on the DDX41-G4-ribosomal biogenesis-p53 pathway.