Award
NIH Reporter #1R15DK142148-01
Role of the parasubthalamic nucleus (PSTN) in the central regulation of feeding behavior
Recipient
Williams College, Williamstown, MA, United States
Award Amount
$427,000.00
Ceiling
$427,000.00
Awarded
April 15, 2025
Identifier
1R15DK142148-01
This NIH grant funds research on the parasubthalamic nucleus's role in appetite suppression, aiming to understand neural mechanisms regulating feeding behavior and identify therapeutic targets for appetite disorders.
Description
The purpose of this proposal is to investigate the role of a relatively unexplored population of neurons in the parasubthalamic nucleus (PSTN) in appetite suppression. The study aims to determine the upstream neurons projecting to the PSTN, hormones influencing the PSTN, and the necessity of PSTN in appetite suppression under various conditions. The research will provide insights into brain regulation of food intake and identify potential therapeutic targets for hunger re-establishment in conditions of appetite loss.