Award
NIH Reporter #PA-24-254
HUMAN PLATELET PAR4: NOVEL ACTIVATION, INTERINDIVIDUAL VARIATION, AND NEUTROPHIL INTERACTIONS IN VIVO AND IN VITRO
Recipient
Washington University, Department of Emergency Medicine
Award Amount
$509,165.00
Ceiling
$509,165.00
Awarded
January 07, 2025
Identifier
PA-24-254
Research project funded by NHLBI to study platelet PAR4 receptor's role in blood reactivity and stroke, aiming to develop personalized therapies.
Description
The project aims to understand the molecular genetic mechanisms contributing to blood platelet reactivity and stroke outcomes, focusing on PAR4 receptor interactions and genetic variations. It involves in vivo and in vitro studies, including mouse models and genetic analysis, emphasizing personalized anti-platelet therapies and racial differences in genetic variants.