Award
National Cancer Institute 1R01CA308007-01A1
Investigating age-dependent factors in the development and treatment of adrenal cancer
Recipient
Utah State Higher Education System--University of Utah
Award Amount
$581,686.00
Ceiling
$581,686.00
Awarded
June 05, 2026
Identifier
1R01CA308007-01A1
Research project investigating the role of cellular senescence in adrenal cancer development and treatment, aiming to develop senolytic therapies targeting senescent cells to improve outcomes.
Description
This project focuses on adrenocortical carcinoma (ACC), a rare but aggressive cancer. The research involves developing a mouse model that mirrors human disease, studying the role of senescent cells in tumor initiation and progression, and testing senolytic drugs to eliminate senescent cells post-therapy. The central hypothesis is that persistent senescent cells become protumorigenic via increased Wnt signaling, which can be targeted with senolytics.