Award
NIH Reporter #5R21CA296062-02
Sequential infection of laboratory mice for enhanced cancer and immunotherapy translation
Recipient
University Health Network, Toronto, Canada
Award Amount
$138,848.00
Ceiling
$138,848.00
Awarded
June 19, 2026
Identifier
5R21CA296062-02
The award funds research to create a mouse model with an adult-like immune system to improve the translation of cancer and immunotherapy studies from mice to humans.
Description
This project aims to develop a novel mouse model that better mimics human immune responses to cancer, facilitating translational research in immunotherapy. The project hypothesizes that the neonatal-like immune system in Specific Pathogen Free (SPF) mice underlies many differences observed between mouse and human anti-tumor responses and proposes to develop lab-generated “wild-like” mice that mimic adult human immune responses to cancer and immunotherapy.