# NIH Reporter #11616276

Integrating Single-Cell TCR Landscapes and Structural Fingerprints to Advance Leukemia Immunotherapies

**Recipient:** University of Houston

**Award Amount:** $526,443.00
**Ceiling:** $526,443.00

**Awarded:** September 09, 2026

**Identifier:** 11616276

Award to University of Houston for a project developing AI-driven structural analysis of TCRs in leukemia immunotherapy, creating a LIMESTone atlas and computational frameworks, funded by NIH NCI.

### Description

The project focuses on developing structure-based analysis of TCRs from AML patients, including AI-driven prediction models. It aims to establish the first Leukemia Immune Micro-Environment Single-TCR (LIMESTone) atlas, involving structural modeling, molecular fingerprinting, and AI techniques such as Graph Neural Networks. The project addresses challenges in TCR analysis for leukemia immunotherapy and aims to create resources including a structural atlas of AML-associated TCRs and a catalog of the antigenic landscape. It will develop new computational frameworks for TCR analysis.

[View original record](https://reporter.nih.gov/search/0C83gI3MXki4-tEhFD4UKQ/project-details/11616276)