Award
National Institute of Allergy and Infectious Diseases 5U01AI126322-12
Strategies to Optimize Pig-to-Primate Kidney Xenograft Survival
Recipient
University of Minnesota
Award Amount
$1,541,316.00
Ceiling
$1,541,316.00
Awarded
July 22, 2026
Identifier
5U01AI126322-12
A NIH-funded project focused on improving pig-to-primate kidney xenograft survival by genetic engineering of pigs and immune response control strategies to prevent rejection and enhance graft longevity.
Description
This project aims to genetically engineer pigs to remove known xenoantigens and test strategies to control immune responses, including the use of anti-CD19 depleting antibodies and CAR T cell therapeutics, to prevent early and late rejection, thereby improving graft survival.