Award
National Heart, Lung, and Blood Institute 5R01HL166512-04
Preserving bone marrow niche integrity and function to rejuvenate aged hematopoietic stem cells
Recipient
University of Florida
Award Amount
$618,310.00
Ceiling
$618,310.00
Awarded
May 19, 2026
Identifier
5R01HL166512-04
This NIH-funded research project focuses on rejuvenating aged hematopoietic stem cells by enhancing Netrin-1 signaling to restore bone marrow niche function and improve blood system health in aging individuals.
Description
The project aims to test whether enhancing the signaling pathway of Netrin-1 (NTN1) can restore the functional capacity of the aging blood system by rejuvenating hematopoietic stem cells (HSCs). It will elucidate cellular and molecular mechanisms by which aging of the bone marrow (BM) niche contributes to HSC decline and validate NTN1 as a therapeutic target.