Award
National Institute of Biomedical Imaging and Bioengineering 3R01EB035631-02S1
Enabling systemic delivery of europium-containing contrast agents for magnetic resonance imaging
Recipient
Wayne State University
Award Amount
$73,092.00
Ceiling
$73,092.00
Awarded
June 08, 2026
Identifier
3R01EB035631-02S1
This NIH-funded project at Wayne State University aims to develop systemically deliverable europium-based MRI contrast agents for hypoxia imaging, which is important for diagnosing diseases like cancer and kidney disease.
Description
The research aims to develop hypoxia-sensing probes for MRI to address unmet diagnostic needs across various diseases. It focuses on phosphonate-containing complexes of EuII that are compatible with systemic delivery, overcoming obstacles such as persistence time and relaxivity. The project builds on previous discoveries of EuII-based agents that persist in blood, aiming to increase their effectiveness through chemical modifications and conjugation to macromolecules. The outcomes will inform the design of EuII complexes for systemic delivery and hypoxia imaging.