Award
National Institute on Deafness and Other Communication Disorders 5R01DC021047-03
Investigating stochastic genome folding as a mechanism to generate cell-surface protein diversity required for neural self-avoidance
Recipient
University of California, San Francisco
Award Amount
$644,418.00
Ceiling
$644,418.00
Awarded
February 05, 2026
Identifier
5R01DC021047-03
NIH awarded a research grant to University of California, San Francisco to study genome folding and cell-surface protein diversity in neural self-avoidance, focusing on Protocadherin gene regulation in mouse olfactory neurons.
Description
This NIH research grant project aims to investigate the mechanism of Protocadherin (Pcdh) gene choice in vivo using mouse olfactory sensory neurons and their progenitor cells by the cohesin protein complex and its regulator WAPL. The study focuses on understanding neural self-avoidance and neural circuit assembly during brain development.