Award
National Institute of Allergy and Infectious Diseases 1R01AI187292-01A1
Defining Protective IgGs to Food Allergy
Recipient
Massachusetts General Hospital
Award Amount
$806,466.00
Ceiling
$806,466.00
Awarded
July 29, 2025
Identifier
1R01AI187292-01A1
A research grant awarded to Massachusetts General Hospital to study IgG antibodies' protective roles in peanut allergy and identify biomarkers for successful oral immunotherapy.
Description
This project aims to define the characteristics of IgG antibodies that protect against peanut allergy, which is relevant to public health due to the burden of food allergies. The research will generate basic immunology knowledge about the roles of IgG and IgE in food allergy and establish biomarkers following oral immunotherapy (OIT). The study involves profiling peanut-specific IgG responses in adults undergoing OIT and identifying signatures associated with successful outcomes.